Dapk3 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comDapk3 CLIA Kit for Rat(Rattus norvegicus)

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Dapk3 (Gene name),

Death-associated protein kinase 3 (Protein name ), DAPK3_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Dapk3(Zipk);

Protein name:

Death-associated protein kinase 3(DAP kinase 3);

Alternative:

ZIP-kinase;DAP-like kinase(Dlk);ZIP-kinase;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. Also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. Interacts with AATF and CDC5L.

Function:

Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth.

Subcellular Location:

Nucleus Cytoplasm Chromosome centromere Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments. Associates to centromeres from prophase to anaphase.

Protein Attributes:

Sequence length:

448

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

448:

AGGLKRRLCR | LENRYDALAA | QVAAEVQFVR | DLVRALEQER | LQAECGVR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.60353

KEGG:

rno:64391

Pfam:

PF00069

String:

O88764

SMR:

O88764

Uniprot:

O88764

FOR

ELISA Kit for Rat DAP kinase 3

Cat.:

E15322m

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96T

ELISA Kit for Rat DAP kinase 3

Cat.:

E15322r

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96T

ELISA Kit for Rat DAP kinase 3

Cat.:

E15322h

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96T

CLIA Kit for Rat DAP kinase 3

Cat.:

U15322h

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96T

CLIA Kit for Rat DAP kinase 3

Cat.:

U15322r

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96T

CLIA Kit for Rat DAP kinase 3

Cat.:

U15322m

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96T

Polyclonal Antibody for Rat DAP kinase 3

Cat.:

P15322Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat DAP kinase 3

Cat.:

P15322Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat DAP kinase 3

Cat.:

P15322Rb-h

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40ug/0.2ml

Monoclonal Antibody for Rat DAP kinase 3

Protein for Rat DAP kinase 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histones."
Koegel D. , Ploettner O. , Landsberg G. , Christian S. , Scheidtmann K.H.
Oncogene17:2645-2654(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;CATALYTIC ACTIVITY;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Prostate.
3.

"AATF -- a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis."
Page G. , Loedige I. , Kogel D. , Scheidtmann K.H.
FEBS Lett.462:187-191(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AATF
4.

"C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activity."
Koegel D. , Bierbaum H. , Preuss U. , Scheidtmann K.H.
Oncogene18:7212-7218(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF 406-ARG-ARG-407
5.

"Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis."
Page G. , Kogel D. , Rangnekar V. , Scheidtmann K.H.
Oncogene18:7265-7273(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;CATALYTIC ACTIVITY;INTERACTION WITH ATF4 AND PAWR;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-42
6.

"Zipper-interacting protein kinase induces Ca(2+)-free smooth muscle contraction via myosin light chain phosphorylation."
Niiro N. , Ikebe M.
J. Biol. Chem.276:29567-29574(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 2);FUNCTION IN PHOSPHORYLATION OF MYL12B AND PPP1R12A;CATALYTIC ACTIVITY
7.

"DAP-like kinase interacts with the rat homolog of Schizosaccharomyces pombe CDC5 protein, a factor involved in pre-mRNA splicing and required for G2/M phase transition."
Engemann H. , Heinzel V. , Page G. , Preuss U. , Scheidtmann K.H.
Nucleic Acids Res.30:1408-1417(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDC5L
8.

"DAP-like kinase, a member of the death-associated protein kinase family, associates with centrosomes, centromers, and the contractile ring during mitosis."
Preuss U. , Bierbaum H. , Buchenau P. , Scheidtmann K.H.
Eur. J. Cell Biol.82:447-459(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
9.

"Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase."
Preuss U. , Landsberg G. , Scheidtmann K.H.
Nucleic Acids Res.31:878-885(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts."
Komatsu S. , Ikebe M.
J. Cell Biol.165:243-254(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MYL12B;SUBCELLULAR LOCATION;CATALYTIC ACTIVITY
11.

"ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene."
Shoval Y. , Pietrokovski S. , Kimchi A.
PLoS Genet.3:1884-1893(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH PAWR;MUTAGENESIS OF ALA-294 AND ALA-295
12.

"ZIP kinase plays a crucial role in androgen receptor-mediated transcription."
Leister P. , Felten A. , Chasan A.I. , Scheidtmann K.H.
Oncogene27:3292-3300(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANDROGEN RECEPTOR-MEDIATED TRANSCRIPTION;INTERACTION WITH AR
13.

"The pro-apoptotic protein Par-4 facilitates vascular contractility by cytoskeletal targeting of ZIPK."
Vetterkind S. , Morgan K.G.
J. Cell. Mol. Med.13:887-895(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PAWR
14.

"Phosphorylation-dependent control of ZIPK nuclear import is species specific."
Weitzel D.H. , Chambers J. , Haystead T.A.
Cell. Signal.23:297-303(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION

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